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Welcome to my research blog for the ICompute program at Brooklyn College (Fall 2024 – Spring 2025). This blog highlights my work on the computational development of peptidomimetic inhibitors targeting EZH2 (Enhancer of Zeste homolog 2)-mediated interactions within the Polycomb Repressive Complex 2 (PRC2). Included are my research progress reports, conference poster and presentations.
Thank you for visiting, and enjoy exploring the project!
— Cassandre Cheriska
Presented at the 72nd Annual NY ACS Undergraduate Research Symposium, University of Mount Saint Vincent — April 26th, 2025
This presentation highlights my computational research on disrupting EZH2’s intramolecular interactions to inhibit PRC2 catalytic activity. Through alanine scanning, MM-GBSA analysis, and AToM-OpenMM simulations, key stabilizing residues were identified to guide peptidomimetic inhibitor design.
Presented at the 34th Annual Brooklyn College Science Day — May 9th, 2025
This poster showcases my research on targeting the SBD–SANT1 intramolecular interaction in EZH2 to inhibit its catalytic activity using computational techniques. I was honored to receive 3rd place for this presentation in the Undergraduate category.
Cassandre Cheriska – ICompute Research Progress Report | Brooklyn College
A research progress journal for Fall 2024 – Spring 2025, detailing the development of peptidomimetic inhibitors targeting EZH2-mediated interactions in PRC2 using computational modeling.
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